[New insights into the seriousness of acute myocardial injury during COVID-19].
Identifieur interne : 000013 ( Main/Exploration ); précédent : 000012; suivant : 000014[New insights into the seriousness of acute myocardial injury during COVID-19].
Auteurs : Camilla Alderighi ; Raffaele Rasoini ; Giuseppe Ambrosio ; Serafina Valente ; Gian Franco GensiniSource :
- Giornale italiano di cardiologia (2006) [ 1972-6481 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- étiologie : Infarctus du myocarde.
- complications : Betacoronavirus, Humains, Infections à coronavirus, Maladie grave, Pandémies, Pneumopathie virale.
English descriptors
- KwdEn :
- MESH :
- complications : Coronavirus Infections, Pneumonia, Viral.
- etiology : Myocardial Infarction.
- Betacoronavirus, Critical Illness, Humans, Pandemics.
Abstract
Retrospective data from Chinese cohorts published in the last few days have placed a strong emphasis on the possibility that acute myocardial injury represents a critical component in the development of serious complications in patients hospitalized with COVID-19. These analyses showed that 19-27% of hospitalized patients with moderate/severe COVID-19 developed acute myocardial injury, defined as an increase in troponin levels. Fifty-sixty percent of these patients died. The highest mortality rate was detected among patients with both progressively incremental troponin levels and a history of cardiovascular disease. Some pathophysiological reasons have been hypothesized regarding the frequently observed increase in troponin levels in patients hospitalized with COVID-19, but, at the moment, these data could already suggest some clinical management implications, also with the aim of prospectively collecting research data: a troponin dosage should be considered, as a prognostic indicator, in all patients with moderate/severe COVID-19 at hospital admission, periodically during hospitalization, and in the case of clinical deterioration. In those patients with increased troponin levels, serial determinations should be carried out to define the enzymatic trajectory and therefore also the degree of clinical attention that must necessarily be closer in those who turn out to have persistently high or increasing troponin levels. In order to reduce the overdiagnosis risk of acute myocardial injury in critically ill patients, detection of increased troponin levels should always be contextualized into a multi-parametric evaluation.
DOI: 10.1714/3343.33128
PubMed: 32310916
Affiliations:
Links toward previous steps (curation, corpus...)
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Maria della Misericordia, Perugia.</nlm:affiliation><wicri:noCountry code="subField">Perugia</wicri:noCountry></affiliation></author><author><name sortKey="Valente, Serafina" sort="Valente, Serafina" uniqKey="Valente S" first="Serafina" last="Valente">Serafina Valente</name><affiliation><nlm:affiliation>Dipartimento Cardio-Toraco-Vascolare, AOU Senese, Siena.</nlm:affiliation><wicri:noCountry code="subField">Siena</wicri:noCountry></affiliation></author><author><name sortKey="Gensini, Gian Franco" sort="Gensini, Gian Franco" uniqKey="Gensini G" first="Gian Franco" last="Gensini">Gian Franco Gensini</name><affiliation><nlm:affiliation>CESMAV (Centro Studi di Medicina Avanzata), Firenze - IRCCS Multimedica, Sesto San Giovanni (MI).</nlm:affiliation><wicri:noCountry code="subField">Sesto San Giovanni (MI)</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32310916</idno><idno type="pmid">32310916</idno><idno type="doi">10.1714/3343.33128</idno><idno type="wicri:Area/Main/Corpus">000347</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000347</idno><idno type="wicri:Area/Main/Curation">000347</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000347</idno><idno type="wicri:Area/Main/Exploration">000347</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[New insights into the seriousness of acute myocardial injury during COVID-19].</title><author><name sortKey="Alderighi, Camilla" sort="Alderighi, Camilla" uniqKey="Alderighi C" first="Camilla" last="Alderighi">Camilla Alderighi</name><affiliation><nlm:affiliation>Ordine dei Medici Chirurghi e degli Odontoiatri della Provincia di Firenze - CESMAV (Centro Studi di Medicina Avanzata), Firenze.</nlm:affiliation><wicri:noCountry code="subField">Firenze</wicri:noCountry></affiliation></author><author><name sortKey="Rasoini, Raffaele" sort="Rasoini, Raffaele" uniqKey="Rasoini R" first="Raffaele" last="Rasoini">Raffaele Rasoini</name><affiliation><nlm:affiliation>Ordine dei Medici Chirurghi e degli Odontoiatri della Provincia di Firenze - CESMAV (Centro Studi di Medicina Avanzata), Firenze.</nlm:affiliation><wicri:noCountry code="subField">Firenze</wicri:noCountry></affiliation></author><author><name sortKey="Ambrosio, Giuseppe" sort="Ambrosio, Giuseppe" uniqKey="Ambrosio G" first="Giuseppe" last="Ambrosio">Giuseppe Ambrosio</name><affiliation><nlm:affiliation>IRCCS Multimedica, Sesto San Giovanni (MI) - Cardiologia e Fisiopatologia Cardiovascolare, Ospedale S. Maria della Misericordia, Perugia.</nlm:affiliation><wicri:noCountry code="subField">Perugia</wicri:noCountry></affiliation></author><author><name sortKey="Valente, Serafina" sort="Valente, Serafina" uniqKey="Valente S" first="Serafina" last="Valente">Serafina Valente</name><affiliation><nlm:affiliation>Dipartimento Cardio-Toraco-Vascolare, AOU Senese, Siena.</nlm:affiliation><wicri:noCountry code="subField">Siena</wicri:noCountry></affiliation></author><author><name sortKey="Gensini, Gian Franco" sort="Gensini, Gian Franco" uniqKey="Gensini G" first="Gian Franco" last="Gensini">Gian Franco Gensini</name><affiliation><nlm:affiliation>CESMAV (Centro Studi di Medicina Avanzata), Firenze - IRCCS Multimedica, Sesto San Giovanni (MI).</nlm:affiliation><wicri:noCountry code="subField">Sesto San Giovanni (MI)</wicri:noCountry></affiliation></author></analytic><series><title level="j">Giornale italiano di cardiologia (2006)</title><idno type="eISSN">1972-6481</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (complications)</term><term>Critical Illness (MeSH)</term><term>Humans (MeSH)</term><term>Myocardial Infarction (etiology)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Betacoronavirus (MeSH)</term><term>Humains (MeSH)</term><term>Infarctus du myocarde (étiologie)</term><term>Infections à coronavirus (complications)</term><term>Maladie grave (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (complications)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Myocardial Infarction</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Infarctus du myocarde</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Betacoronavirus</term><term>Critical Illness</term><term>Humans</term><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Betacoronavirus</term><term>Humains</term><term>Infections à coronavirus</term><term>Maladie grave</term><term>Pandémies</term><term>Pneumopathie virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Retrospective data from Chinese cohorts published in the last few days have placed a strong emphasis on the possibility that acute myocardial injury represents a critical component in the development of serious complications in patients hospitalized with COVID-19. These analyses showed that 19-27% of hospitalized patients with moderate/severe COVID-19 developed acute myocardial injury, defined as an increase in troponin levels. Fifty-sixty percent of these patients died. The highest mortality rate was detected among patients with both progressively incremental troponin levels and a history of cardiovascular disease. Some pathophysiological reasons have been hypothesized regarding the frequently observed increase in troponin levels in patients hospitalized with COVID-19, but, at the moment, these data could already suggest some clinical management implications, also with the aim of prospectively collecting research data: a troponin dosage should be considered, as a prognostic indicator, in all patients with moderate/severe COVID-19 at hospital admission, periodically during hospitalization, and in the case of clinical deterioration. In those patients with increased troponin levels, serial determinations should be carried out to define the enzymatic trajectory and therefore also the degree of clinical attention that must necessarily be closer in those who turn out to have persistently high or increasing troponin levels. In order to reduce the overdiagnosis risk of acute myocardial injury in critically ill patients, detection of increased troponin levels should always be contextualized into a multi-parametric evaluation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32310916</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>22</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1972-6481</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>5</Issue><PubDate><Year>2020</Year><Month>May</Month></PubDate></JournalIssue><Title>Giornale italiano di cardiologia (2006)</Title><ISOAbbreviation>G Ital Cardiol (Rome)</ISOAbbreviation></Journal><ArticleTitle>[New insights into the seriousness of acute myocardial injury during COVID-19].</ArticleTitle><Pagination><MedlinePgn>328-331</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1714/3343.33128</ELocationID><Abstract><AbstractText>Retrospective data from Chinese cohorts published in the last few days have placed a strong emphasis on the possibility that acute myocardial injury represents a critical component in the development of serious complications in patients hospitalized with COVID-19. These analyses showed that 19-27% of hospitalized patients with moderate/severe COVID-19 developed acute myocardial injury, defined as an increase in troponin levels. Fifty-sixty percent of these patients died. The highest mortality rate was detected among patients with both progressively incremental troponin levels and a history of cardiovascular disease. Some pathophysiological reasons have been hypothesized regarding the frequently observed increase in troponin levels in patients hospitalized with COVID-19, but, at the moment, these data could already suggest some clinical management implications, also with the aim of prospectively collecting research data: a troponin dosage should be considered, as a prognostic indicator, in all patients with moderate/severe COVID-19 at hospital admission, periodically during hospitalization, and in the case of clinical deterioration. In those patients with increased troponin levels, serial determinations should be carried out to define the enzymatic trajectory and therefore also the degree of clinical attention that must necessarily be closer in those who turn out to have persistently high or increasing troponin levels. In order to reduce the overdiagnosis risk of acute myocardial injury in critically ill patients, detection of increased troponin levels should always be contextualized into a multi-parametric evaluation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Alderighi</LastName><ForeName>Camilla</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Ordine dei Medici Chirurghi e degli Odontoiatri della Provincia di Firenze - CESMAV (Centro Studi di Medicina Avanzata), Firenze.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rasoini</LastName><ForeName>Raffaele</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Ordine dei Medici Chirurghi e degli Odontoiatri della Provincia di Firenze - CESMAV (Centro Studi di Medicina Avanzata), Firenze.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ambrosio</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>IRCCS Multimedica, Sesto San Giovanni (MI) - Cardiologia e Fisiopatologia Cardiovascolare, Ospedale S. Maria della Misericordia, Perugia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valente</LastName><ForeName>Serafina</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Dipartimento Cardio-Toraco-Vascolare, AOU Senese, Siena.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gensini</LastName><ForeName>Gian Franco</ForeName><Initials>GF</Initials><AffiliationInfo><Affiliation>CESMAV (Centro Studi di Medicina Avanzata), Firenze - IRCCS Multimedica, Sesto San Giovanni (MI).</Affiliation></AffiliationInfo></Author></AuthorList><Language>ita</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Nuove acquisizioni sulla gravità del danno cardiaco acuto in corso di COVID-19.</VernacularTitle></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>G Ital Cardiol (Rome)</MedlineTA><NlmUniqueID>101263411</NlmUniqueID><ISSNLinking>1827-6806</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>G Ital Cardiol (Rome). 2020 Jun;21(6):478</RefSource><PMID Version="1">32425194</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009203" MajorTopicYN="N">Myocardial Infarction</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32310916</ArticleId><ArticleId IdType="doi">10.1714/3343.33128</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Alderighi, Camilla" sort="Alderighi, Camilla" uniqKey="Alderighi C" first="Camilla" last="Alderighi">Camilla Alderighi</name><name sortKey="Ambrosio, Giuseppe" sort="Ambrosio, Giuseppe" uniqKey="Ambrosio G" first="Giuseppe" last="Ambrosio">Giuseppe Ambrosio</name><name sortKey="Gensini, Gian Franco" sort="Gensini, Gian Franco" uniqKey="Gensini G" first="Gian Franco" last="Gensini">Gian Franco Gensini</name><name sortKey="Rasoini, Raffaele" sort="Rasoini, Raffaele" uniqKey="Rasoini R" first="Raffaele" last="Rasoini">Raffaele Rasoini</name><name sortKey="Valente, Serafina" sort="Valente, Serafina" uniqKey="Valente S" first="Serafina" last="Valente">Serafina Valente</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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